HIV/AIDS has become a lifelong treatment with the advancement of anti-retrovirus therapy(ART). The purpose of this study was to study the effect of Neuro-Linguistic Programming (NLP)counseling program on PLWHA who were receiving ART. The sample consisted of 64 PLWHA whowere receiving ART for at least one year, whose physician had diagnosed them as having poorART adherence and receiving a score of ≤ 90% on Wantana’s self-report adherence evaluationsheet 2004. The group was divided into two groups of 32 people by a process of simple randomsampling. The experimental group received general advice and the NLP counseling program,while the control group received the general advice from the servicing clinic. The research designwas a pretest-posttest experimental group design, including follow-up testing after 2 months.The data were statistically analyzed by utilizing a repeated measures analysis of variance. Theresults revealed that the interaction between the methods and the duration of the experimentwas found to be significant (p < .01). The PLWHA who received the NLP counseling demonstratedsignificantly higher ART adherence than the control group in both the posttest and follow-upphases (p < .01). The PLWHA in the experimental group had significantly higher adherence in theposttest and follow-up phases than the pretest phase (p < .01). Thereafter the NLP counselingcould be used for the health service clinic which saved time and effectiveness, are needed.