Lipid Hydroperoxide, Malondialdehyde and Total Anitioxidant Capacity As Predictors for Oxidative Stress in Type 2 Diabetes Mellitus

Abstract

Objective: Lipid Hydroperoxide (LOOH) and malondialdehyde (MDA), products of lipid peroxidation, are occurring cellular process and involved in cell adhesion and proliferation, inflammatory responses, aging, and death. Lipid peroxidation plays an important role in the premature development of atherosclerosis. We aim to determine the KOOH, MDA, and total antioxidant capacity (TAC) as the markers of oxidative stress in type 2 diabetes (T2D) patients.  Materials and Methods: The study included 206 participants stratified as 123 T2D (with 37 males and 86 females) and 83 healthy controls (with 18 males and 65 females) randomly selected from Phitsanulok residents. MDA, LOOH, TAC levels and others biochemical markers were measured from the blood samples of these participants. Results: LOOH and MDA levels were significantly higher (P < 0.05), and TAC was lower in T2D patients. There were associations between elevated LOOH (OR = 12.86; 95% CI 5023-31.63), MDA (OR = 8.54; 95% CI 3.15-23.18), hypertriglyceridemia (OR = 3.96; 95% CI 1.49-1.48), abdominal obesity (OR = 4.05; 95% CI 1.58-10.35) and T2D adjusting for age and gender. Increased LOOH and MDA level, and decreased TAC levels are indicated oxidative stress occurred in T2D patients.  Conclusion: Our results revealed that T2D patients had elevate oxidative stress enzymes that may cause oxidative damage. Therefore, LOOH, MDA and TAC assays are the good markers for predicting oxidative stress in T2D